Public trust in science and institutional expertise has plummeted in recent years. Research shows many members from Indigenous communities deeply distrust Western science due to its complicity in historical and ongoing colonial violence. Indigenous communities’ mistrust of Western science is rooted in past exploitations, such as the use of Indigenous peoples as research subjects without their consent, the misuse of health data, the theft of cultural resources, and the manipulation of wildlife. Indigenous Food Sovereignty (IFS), which is inseparable from Indigenous Seed Sovereignty (ISS), is gravely threatened by climate change. The expanding influence of multinational agricultural corporations on the crop biotechnology sector and their monopolistic tendencies within a colonial and capitalist framework pose serious threats to the sovereignty of Indigenous seed systems. Empirical research reveals that crop biotechnology rooted in Western science can contribute to developing climate-resilient seed systems. Indigenous communities, due to their mistrust of Western science, frequently view its adoption with skepticism. Alam’s research will examine the intricate relationship between Indigenous communities and settler-colonial technoscientific practices in the context of increasingly globalized agricultural models, which frequently prioritize Western scientific techniques and seed monopolies over traditional farming practices. Central to this research is the concept of 'seed sovereignty,' which refers to the right of Indigenous Peoples to save, breed, and exchange seeds, allowing them to maintain ecological biodiversity and recover Indigenous agricultural practices crucial for their food sovereignty as well as their cultural and spiritual well-being. This study will explore both the historical and current socioeconomic, cultural-political, and technoscientific factors that shape Indigenous Peoples' perceptions and trust in Western science in the context of seed systems and its implications for Indigenous Seed Sovereignty in Northern Ontario.